PRP Tube nge Gel
Incazelo emfushane:
Abstract.Okuzenzakalelayoi-plasma ene-platelet ecebile(PRP) ijeli isetshenziswa ngokuqhubekayo ekwelapheni ukukhubazeka okuhlukahlukene kwezicubu ezithambile namathambo, njengokusheshisa ukwakheka kwamathambo kanye nokuphathwa kwezilonda ezingapheli ezingapholi.
Wonke amangqamuzana egazi aphuma kuseli elivamile le-pluripotent stem, elihlukanisa libe imigqa yamaseli ehlukene.Ngalunye lwalolu chungechunge lwamaseli luqukethe izandulela ezingahlukanisa futhi zivuthwe.
Ama-platelet, abizwa nangokuthi ama-thrombocyte, akhula emnkantsheni.Ama-Platelets ayi-nucleated, izakhi zamaseli e-discoid ezinosayizi abahlukene kanye nokuminyana okungaba ngu-2 μm ububanzi, ukuminyana okuncane kakhulu kwawo wonke amangqamuzana egazi.Isibalo sokuphila sama-platelet ajikeleza emgudwini wegazi sisukela ku-150,000 kuya ku-400,000 amaplatelet nge-μL.
Ama-platelet aqukethe ama-granules ambalwa ayimfihlo abalulekile ekusebenzeni kweplatelet.Kunezinhlobo ezi-3 zama-granules: ama-granules aminyene, ama-o-granules, nama-lysosomes.Ku-platelet ngayinye kukhona cishe ama-granules angama-50-80, iningi lezinhlobo ezi-3 zama-granules.
Ama-platelet anesibopho ngokuyinhloko ngenqubo yokuhlanganisa.Umsebenzi oyinhloko ukufaka isandla kuzinqubo ezi-3 ze-homeostasis: ukunamathela, ukwenza kusebenze, nokuhlanganisa.Ngesikhathi sokulimala kwemithambo, amaplatelet ayasebenza, futhi ama-granules awo akhulula izici ezikhuthaza ukuhlangana.
Ama-platelet ayecatshangwa ukuthi anomsebenzi we-hemostatic kuphela, nakuba eminyakeni yamuva nje, ucwaningo lwesayensi nobuchwepheshe bunikeze umbono omusha kuma-platelet nemisebenzi yawo.Ucwaningo luphakamisa ukuthi ama-platelet aqukethe inqwaba yama-GF nama-cytokines angathinta ukuvuvukala, i-angiogenesis, ukufuduka kwamangqamuzana e-stem, nokwanda kwamangqamuzana.
I-PRP iwumthombo wemvelo wamangqamuzana okubonisa, futhi lapho kwenziwa ukusebenza kwama-platelet ku-PRP, ama-P-granules aba yi-granulated futhi akhulule ama-GF nama-cytokines azoshintsha i-microenvironment yeselula ngayinye.Amanye ama-GF abaluleke kakhulu akhishwe ama-platelet ku-PRP ahlanganisa i-vascular endothelial GF, i-fibroblast GF (FGF), i-GF etholakala ku-platelet, i-epidermal GF, i-hepatocyte GF, i-insulin-like GF 1, 2 (IGF-1, IGF-2), i-matrix metalloproteinase 2, 9, kanye ne-interleukin 8.
