I-HA PRP Collection Tube
Incazelo emfushane:
I-HA i-hyaluronic acid, evame ukubizwa ngokuthi i-hyaluronic acid, Igama eligcwele lesiNgisi: i-hyaluronic acid.I-Hyaluronic acid ingeyomndeni we-glycosaminoglycan, owakhiwa amayunithi aphindaphindwayo e-disaccharide.Izomuncwa futhi iboliswe umzimba womuntu.Isikhathi sayo sokusebenza side kuneso se-collagen.Ingandisa isikhathi sesenzo ngokuxhumanisa, futhi umphumela ungahlala izinyanga eziyi-6-18.
Izinguquko eziyinhloko ze-pathophysiological ze-knee osteoarthritis ukulahlekelwa kwe-cartilage, ukwakhiwa kabusha kwamathambo e-subchondral, ukwakheka kwe-osteophyte kanye nokusabela kokuvuvukala kwe-synovial.Ukubonakaliswa kokuqala komtholampilo ukuvuvukala, ubuhlungu nokuqina kwamalunga nezicubu ezizungezile.Ngokuqhubeka kwalesi sifo, kancane kancane kuholela ekungasebenzi kahle kwamalunga futhi kuthinte kakhulu izinga lempilo.Ngokocwaningo, izinga lokukhubazeka kwe-osteoarthritis emhlabeni wonke lalingu-2.2% ngo-2010, futhi isibalo sabakhubazekile ngonyaka ofanayo sadlula izigidi ezingu-1.7, okwaletha umonakalo omkhulu emphakathini, emindenini nakubantu ngabanye.I-HA iyi-molecular polysaccharide biomaterial ephezulu eyakhiwe ukushintshaniswa okuphindaphindiwe kwe-n-acetylglucuronic acid.Iyingxenye eyinhloko ye-synovial fluid ehlangene futhi enye yezingxenye ze-matrix ye-cartilage.Idlala indima ekudleni nasekuvikeleni amalunga.I-HA ekwelapheni i-osteoarthritis kuye kwafakazelwa ngokomtholampilo ukuthi inomphumela othile ekudambiseni izimpawu zobuhlungu bamadolo nokuthuthukisa ukuhamba kwamadolo.Kodwa-ke, ngenxa yokuntuleka kokusekelwa okusekelwe ebufakazini, ikakhulukazi ukusebenza kahle kwesikhathi eside okungaqiniseki, imihlahlandlela ye-AAOS yakamuva yokuxilongwa nokwelashwa kwe-knee osteoarthritis ayincomi ukusetshenziswa kwe-hyaluronic acid, futhi izinga lokuncoma linconywa kakhulu.I-Triamcinolone acetonide, njenge-glucocorticoid yokwenziwa esebenza isikhathi eside, inomphumela oqinile futhi ohlala njalo wokulwa nokuvuvukala.
Indlela yayo ukuvimbela i-phagocytosis kanye nokucubungula ama-antigen ngama-macrophages;Zinzisa ulwelwesi lwe-lysosomal futhi unciphise ukukhululwa kwe-hydrolase ku-lysosome;Vimbela ukufuduka kwama-leukocyte nama-macrophages aphume emithanjeni yegazi futhi unciphise ukusabela kokuvuvukala.Lolu cwaningo luphakamisa ukuthi umphumela womjovo we-intra-articular we-triamcinolone acetonide muhle phakathi nenyanga eyodwa ngemva kokwelashwa, kodwa ngesikhathi sokuthatha umhlalaphansi, ikakhulukazi ngemva kwezinyanga ezingu-6 zokwelashwa, umphumela uba ngaphansi ngokuphawulekayo kwamanye amaqembu amabili.I-Mcalindon nezinye izifundo zibonise ukuthi ezigulini ezinezimpawu ezine-knee osteoarthritis, umjovo we-intraarticular we-triamcinolone acetonide ubangele ukulahlekelwa okukhulu kwevolumu ye-cartilage futhi akukho mehluko obalulekile ebuhlungu bamadolo uma kuqhathaniswa nosawoti ovamile.
Lezi zifundo ezingenhla azikusekeli lokhu kwelashwa kweziguli ezinezimpawu ezine-knee osteoarthritis.Abanye abacwaningi baye basebenzisa i-triamcinolone acetonide kanye ne-sodium hyaluronate intra-articular injection ukuze baphathe i-knee osteoarthritis, futhi ukusebenza kwayo kwesikhathi esifushane nesikhathi eside kungcono kune-hyaluronic acid kuphela.Njengokwelashwa okusha, i-PRP ingatholwa egazini lesiguli le-autologous peripheral, ngaphandle kokwenqatshwa kwamasosha omzimba, futhi iqukethe ukugxila okuphezulu kwezici zokukhula.Izici zokukhula ziye zafakazelwa ukukhuthaza ukwanda kwe-chondrocyte kanye ne-extracellular matrix synthesis.Ngaphezu kwalokho, ucwaningo lwamuva luye lwabonisa ukuthi i-PRP ingavimbela ukuvuvukala kwamahhala kwebhaktheriya kwe-synovium ngezinga elithile ngenkathi ikhuthaza ukuvuselelwa kwe-chondrocyte.Ukuhlolwa okwengeziwe kwezilwane kanye nezifundo zomtholampilo kuphakamisa ukusebenza kahle kwayo.Lolu cwaningo lubonisa ukuthi isikolo se-WOMAC se-PRP ku-1 kanye nezinyanga ezingu-3 ngemva kokwelashwa silingana ne-hyaluronic acid, futhi isikolo se-WOMAC se-PRP ezinyangeni ezingu-6 ngemva kokwelashwa singcono kunamanye amaqembu amabili, okusikisela ukuthi umphumela omuhle wokwelapha wesikhathi esimaphakathi nesikhathi eside.Kodwa-ke, ngenxa yokuntuleka kocwaningo lokulandela umtholampilo lwesikhathi eside lwamasampula amakhulu kanye nokuntuleka kokusekelwa okuqondile okuvela ku-biology yamangqamuzana noma imaging ye-MRI, ucwaningo olwengeziwe kanye nengxoxo kusadingeka.
