Izindlela zokwelapha ezisafufusa zamaselula ezisebenzisa i-platelet-rich plasma (PRP) zinamandla okudlala indima ehambisanayo ezinhlelweni ezihlukahlukene zokwelashwa kwemithi evuselelayo.Kunesidingo esingahlangani somhlaba wonke samasu okulungisa izicubu zokwelapha i-musculoskeletal (MSK) kanye nokuphazamiseka komgogodla, i-osteoarthritis (OA), kanye neziguli ezinezilonda ezingapheli eziyinkimbinkimbi kanye ne-recalcitrant.Ukwelashwa kwe-PRP kusekelwe eqinisweni lokuthi izici zokukhula kweplatelet (PGFs) zisekela izigaba ezintathu zokuphulukiswa kwesilonda nokulungisa i-cascade (ukuvuvukala, ukwanda, ukulungiswa kabusha).
Izinhlobo eziningi ezahlukene ze-PRP ziye zahlolwa, kusukela ezifundweni zabantu, in vitro, nezilwane.Kodwa-ke, izincomo ezivela ocwaningweni lwe-in vitro nolwezilwane zivame ukuholela emiphumeleni yomtholampilo ehlukene ngoba kunzima ukuhumusha imiphumela yocwaningo olungezona ezomtholampilo kanye nezincomo zendlela kuzinqubo zokwelapha zokwelashwa kwabantu.Eminyakeni yamuva nje, kuye kwenziwa inqubekelaphambili ekuqondeni ubuchwepheshe be-PRP kanye nemiqondo yokwakhiwa kwe-bio, futhi iziqondiso ezintsha zocwaningo nezinkomba ezintsha ziye zaphakanyiswa.Kulesi sibuyekezo, sizoxoxa ngentuthuko yakamuva mayelana nokulungiswa kwe-PRP nokubunjwa mayelana ne-platelet dosing, imisebenzi ye-leukocyte ephathelene ne-innate and adaptive immunomodulation, imiphumela ye-serotonin (5-HT), nokubulawa kobuhlungu.Ngaphezu kwalokho, sixoxa ngezinqubo ze-PRP ezihlobene nokuvuvukala kanye ne-angiogenesis ekulungiseni izicubu kanye nezinqubo zokuvuselela kabusha.Okokugcina, sizobuyekeza umphumela wezidakamizwa ezithile emsebenzini we-PRP, kanye nenhlanganisela ye-PRP kanye nezinqubo zokuvuselela.
I-PRP Terminology and Classification
Ukuthuthukiswa kwemikhiqizo ye-PRP ukuze kukhuthazwe ukulungiswa nokuvuselelwa kwezicubu kube inkambu ebalulekile yocwaningo kusayensi ye-biomaterial kanye nemithi amashumi eminyaka.I-cascade yokuphulukisa izicubu ihlanganisa abadlali abaningi, okuhlanganisa ama-platelet anesici sabo sokukhula kanye nama-cytokine granules, ama-leukocyte, i-fibrin matrix, namanye ama-cytokines amaningi, asebenza ngokubambisana.Phakathi nalesi sigameko, inqubo eyinkimbinkimbi yokuhlanganisa iyenzeka, ehlanganisa ukusebenza kweplatelet kanye nokukhululwa okulandelayo kokuqukethwe kwama-granules aminyene kanye ne-α-platelet, i-polymerization ye-fibrinogen (ekhishwe ngama-platelet noma mahhala ku-plasma) ibe yi-fibrin mesh, kanye nokuthuthukiswa kwepulaki yeplatelet. .
Isikhathi sokuthumela: Oct-13-2022