I-knee osteoarthritis (KOA) yisifo esivamile sokukhubazeka kwamadolo esibonakala ngokuwohloka kwe-cartilage, i-cartilage exfoliation, ne-subchondral bone hyperplasia, okuholela ebuhlungu bedolo, ukungazinzi kwamalunga kanye nokulinganiselwa kokusebenza.I-KOA ithinta kakhulu izinga lempilo yeziguli futhi iyinkinga enkulu yezempilo yomphakathi.Ucwaningo lwe-epidemiological olushicilelwe ku-Proceedings of the National Academy of Sciences (PNAS) lubonise ukuthi izehlakalo ze-KOA kubantu base-US ziphindeke kabili kusukela maphakathi nekhulu lamashumi amabili.I-KOA isiphenduke isifo esihlasela abantu kakhulu futhi isidale umthelela omubi kakhulu ezimpilweni zabantu nasemsebenzini.
I-Osteoarthritis Society International (OARSI) incoma ukwelashwa okuvamile kunokuhlinzwa njengesixazululo somugqa wokuqala sokuphatha se-KOA, esigcizelela ukubaluleka kokwelashwa okuvamile ekwelapheni i-KOA.I-American College of Rheumatology (ACR) ihlongoze ukuhlukaniswa ngezigaba lapho ukwelashwa okuvamile kuhlanganisa ukwelashwa kwezidakamizwa nokwelashwa okungezona izidakamizwa.Ukwelashwa okungezona izidakamizwa kuhlanganisa ukuvivinya umzimba okuvamile nokuzivocavoca kwemisipha, kodwa izindlela ezingezona izidakamizwa ngokuvamile zincike kakhulu ekuthotshelweni kwesiguli futhi kunzima ukuzilawula.Imithi yokwelapha eyinhloko ihlanganisa ama-analgesics, izidakamizwa ezingezona ukuvuvukala kanye nemijovo ye-corticosteroid.Nakuba lezi zindlela zokwelapha ezingenhla zisebenza kahle ngezinga elithile, kukhona nemiphumela engemihle emikhulu.Eminyakeni yamuva nje, kuye kwaba nenani elikhulayo lezifundo ngokusetshenziswa komjovo we-intra-articular we-plasma ecebile ngeplatelet (PRP) noma i-hyaluronic acid (HA) ekwelapheni i-KOA.Ukubuyekezwa okuningi okuhlelekile kuphakamisa ukuthi umjovo we-intra-articular we-PRP, uma kuqhathaniswa ne-HA, unganciphisa izimpawu zobuhlungu futhi uthuthukise ukusebenza kwamadolo ezigulini ezine-KOA.Kodwa-ke, ukuhlolwa okulawulwa ngokungahleliwe okuphindwe kabili okuyizimpumputhe okulandelwa iminyaka engu-5 kubonise ukuthi inhlanganisela ye-HA ne-PRP ithuthukise ubuhlungu nokusebenza ezigulini ezinomlando wezinguquko ezingapheli zezimpawu zokuguga kwamadolo kanye ne-osteoarthritis.I-RCT ibonise ukuthi i-PRP iyindlela yokwelapha ephumelelayo ye-KOA emnene kuya kokulinganisela nokuthi ukusetshenziswa okuhlangene kwe-HA ne-PRP kungcono kunokusetshenziswa kwe-HA (unyaka ongu-1) kanye ne-PRP (izinyanga ezingu-3) kuphela.I-RCT iphinde yembula ukuthi i-PRP ayihlinzeki ngentuthuko engcono kakhulu yomtholampilo kune-HA mayelana nokuthuthukiswa kwezimpawu-umsebenzi ezindaweni ezihlukene zokulandela noma ngokwesikhathi somphumela.Eminyakeni yamuva, inani elikhulayo lezifundo ligxile ekuhlakanipheni kwe-PRP kuhlanganiswe ne-HA ye-KOA, futhi izindlela zabo ziye zaxoxwa ngokujulile.Izifundo zokuhlola eziqhathanisa amandla okufuduka kwamaseli e-tendon kanye ne-synovial fibroblasts kusixazululo esihlanzekile se-PRP kanye nesisombululo se-PRP kanye ne-HA kubonise ukuthi ukuxuba i-PRP ne-HA kungathuthukisa kakhulu ukuhamba kwamaseli.U-Marmotti wathola ukuthi ukungezwa kwe-HA ku-PRP kungakhuthaza ngokuphumelelayo ukwanda kwama-chondrocyte futhi kuthuthukise ikhono lokulungiswa kwe-cartilage.Ucwaningo luye lwabonisa ukuthi ukuhlanganiswa kwe-PRP ne-HA kungase kuzuze ezindleleni zayo ezihlukahlukene zezinto eziphilayo futhi kube lula umsebenzi wamangqamuzana esignali njengama-molecule avuthayo, ama-enzyme e-catabolic, ama-cytokines kanye nezici zokukhula, ngaleyo ndlela edlala indima enhle ekwelapheni i-KOA.
Isikhathi sokuthumela: Nov-07-2022