Ukuvuselelwa Kwamathambo kanye ne-Bioengineering

I-PRP sekuyisikhathi eside ichazwa njenge-plasma ye-autologous ene-concentration of platelet ephakeme kakhulu kunegazi elivamile.Imiphumela ye-PRP incike ekusebenzeni okuyingqayizivele kwezinto eziphilayo zamaplatelet kanye nokubandakanyeka kwabo ekuphulukiseni isilonda kwe-cascade.Umsebenzi oyinhloko wama-platelet ukwakha ipulaki ye-hemostatic kanye nokukhuthaza ukukhiqizwa kwe-fibrin kanye nokujiya kwegazi ukuvimbela ukulahleka kwegazi.Kodwa-ke, nazo ziyingxenye ebalulekile yokusabela okungokwemvelo kokuzivikela komzimba.Balwa nokutheleleka futhi balungise ukuvuvukala, bakhuthaze i-chemotaxis yamangqamuzana nokwanda, futhi bakhuthaze ukuphulukiswa kwesilonda, i-angiogenesis, nokwakheka kwamathambo.

Ngaphakathi kwama-platelet, umthombo omningi kakhulu wamaprotheni afihliwe yi-α-granule.Amaprotheni afihliwe angahlanganiswa emindenini ehlukene ngokusekelwe emsebenzini wawo wezinto eziphilayo.Izinto ezifana ne-PDGF, IGF-1, VEGF, namanye ama-chemokines nama-cytokines amaningana athanda ukuphulukiswa kwesilonda futhi akhuthaze i-angiogenesis ngokubambisana nabaxhumanisi be-proangiogenic njenge-SDF-1, MMP-1, MMP-2, MMP-9, kanye ne-angiopoietin nazo zikhona.I-FGF-2 iyisici se-mitogenic kanye ne-TGF-β1 eyaziwa nangokuthi iqoqa amangqamuzana avuthayo esilondeni.IGF-1 ivuselela ukwakheka kwe-matrix.Amaprotheni okunamathela angasebenza njengama-molecule e-adhesion yamaseli ngaleyo ndlela alamula ukufuduka kwamangqamuzana nawo akhululwa ama-platelet. .

I-molecule ekhulayo ye-CD40 ligand ekhona kulwelwesi lweplatelet kukholakala ukuthi idlala indima ebalulekile ekuvuseni i-angiogenesis ngokugqugquzela ukwanda kwamaseli e-endothelial.I-BMP-2, BMP-4, ne-BMP-6 ahlanganiswa ngama-megakaryocyte futhi akhishwe ama-platelet endaweni ene-acidic hypoxic yokuphuka kwethambo.Ngempela, kuye kwaphakanyiswa ukuthi i-PRP igqugquzela ukuhlukaniswa kwe-osteoblastic ye-myoblasts nama-osteoblasts phambi kwe-BMP-2, BMP-4, BMP-6, ne-BMP-7 ngokunokwenzeka ngokudlala indima engaba namandla ekwahlukeni kwe-osteoblastic encike ku-BMP.