Kusukela ekusungulweni kokuvimbela inzalo kowesifazane ngo-1950s kuya ekuzalweni kwe-test tube baby ngo-1970 kanye nokuhlanganiswa ngempumelelo kwezimvu zika-Dolly ngasekupheleni kwawo-1990, ubuchwepheshe bemithi yokuzala buye benza intuthuko enkulu ubuchwepheshe bokuzala obusiza abantu (Ubuciko) ikakhulukazi ubuchwepheshe obukhethekile. ukusiza lezo ziguli ezingakakwazi ukukhulelwa ngemva kokwelashwa okuvamile ukuhlanganisa amaqanda nesidoda ngokwenziwa ngaphansi kwezimo zaselabhorethri ukuze kuzuzwe ukukhulelwa.Njengoba lobu buchwepheshe buhlukanisa ngokuphelele ubulili nokuzala, ukuthuthukiswa kwayo ngokushesha kuye kwaletha uchungechunge lwezinkinga zokuziphatha, zomthetho nezenhlalakahle, okwenza ukuthuthukiswa kobuciko kuhluke kakhulu kwezinye iziyalo zezokwelapha, kube umuthi okhula ezingxabano.
I-infertility yisifo sesistimu yokuzala esibonakala ngokwehluleka ukukhulelwa ngokomtholampilo ngemva kwezinyanga ezingu-12 noma ngaphezulu zocansi olujwayelekile ngaphandle kokuvimbela inzalo.Izinga lokungatholi abantwana emhlabeni jikelele linyuke lisuka ku-11% ngo-1997 laya ku-15.4% ngo-2018, kanti kulindeleke ukuthi linyuke lifinyelele ku-17.2% ngo-2023. Ukwanda kokungatholi abantwana e-United States kulindeleke ukuthi kunyuke kusuka ku-16% ngo-2018 kuya ku-17.9% ngo-2023. 2023, kuyilapho izinga lokungazali e-China kulindeleke ukuthi likhuphuke lisuka ku-16.0% ngo-2018 liye ku-18.2% ngo-2023.