I-PRP Mechanism of Action in Alopecia

Ama-GF kanye nama-molecule e-bioactive akhona ku-PRP akhuthaza izenzo ezi-4 eziyinhloko endaweni yendawo yokuphatha, njengokwanda, ukufuduka, ukuhlukaniswa kwamaseli, kanye ne-angiogenesis.Ama-cytokines ahlukahlukene kanye nama-GF abandakanyeka ekulawulweni kwe-morphogenesis yezinwele kanye nokukhula kwezinwele zomjikelezo.

Amaseli e-dermal papilla (DP) akhiqiza ama-GF afana ne-IGF-1, i-FGF-7, i-hepatocyte ukukhula factor, kanye ne-vascular endothelial growth factor enesibopho sokugcina i-follicle yezinwele esigabeni se-anagen somjikelezo wezinwele.Ngakho-ke, okungase kube okuhlosiwe kungaba ukulawula lawa ma-GF ngaphakathi kwamaseli e-DP, anweba isigaba se-anagen.

Ngokusho kocwaningo olwenziwa ngu-Akiyama et al, ukukhula kwe-epidermal factor kanye nokuguqula ukukhula kwesici kuhilelekile ekulawuleni ukukhula nokuhlukaniswa kwamangqamuzana e-bulge, futhi isici sokukhula esitholakala ku-platelet singase sibe nemisebenzi ehlobene ekusebenzelaneni phakathi kwe-bulge kanye nezicubu ezihambisanayo, ukuqala nge-follicle morphogenesis.

Eceleni kwama-GF, isigaba se-anagen siphinde senziwe sisebenze yi-Wnt/β-catenin/T-cell factor lymphoid enhancer.Kumaseli e-DP, ukusebenza kwe-Wnt kuzoholela ekuqoqweni kwe-β-catenin, okuthi, ngokuhambisana ne-T-cell factor lymphoid enhancer, iphinde isebenze njenge-co-activator yokubhala futhi ikhuthaze ukwanda, ukusinda, kanye ne-angiogenesis.Amaseli e-DP abe eseqala ukuhlukanisa futhi ngenxa yalokho ukuguquka kusuka ku-telogen kuya esigabeni se-anagen.Ukusayinda i-β-Catenin kubalulekile ekuthuthukiseni i-follicle yomuntu kanye nomjikelezo wokukhula kwezinwele.

igazi lokuqoqwa kwe-prp tube

 

 

Enye indlela eyethulwe ku-DP ukusebenzisa amasignali e-extracellular signal-regulated kinase (ERK) kanye ne-protein kinase B (Akt) ekhuthaza ukusinda kwamaseli futhi ivimbele i-apoptosis.

Indlela eqondile i-PRP ekhuthaza ngayo ukukhula kwezinwele ayiqondi ngokugcwele.Ukuhlola izindlela ezingenzeka ezihilelekile, u-Li et al, wenza ucwaningo oluklanywe kahle ukuze aphenye imiphumela ye-PRP ekukhuleni kwezinwele usebenzisa amamodeli e-in vitro kanye ne-vivo.Kumodeli ye-in vitro, i-PRP ecushiwe yasetshenziswa kumaseli e-DP yomuntu atholwe esikhumbeni esivamile sekhanda lomuntu.Imiphumela ibonise ukuthi i-PRP yandisa ukwanda kwamaseli e-DP yomuntu ngokuvula i-ERK ne-Akt ukusayina, okuholela emiphumeleni ye-antiapoptotic.I-PRP iphinde yandisa umsebenzi we-β-catenin kanye nenkulumo ye-FGF-7 kumaseli e-DP.Mayelana nemodeli ye-vivo, amagundane ajovwe nge-PRP ecushiwe abonise uguquko olusheshayo lwe-telogen-to-anagen uma kuqhathaniswa neqembu lokulawula.

Muva nje, uGupta noCarviel baphinde bahlongoza indlela yesenzo se-PRP ku-follicles yomuntu ehlanganisa "ukukhishwa kwezindlela zokusayina ze-Wnt/β-catenin, ERK, kanye ne-Akt ezikhuthaza ukusinda kwamaseli, ukwanda, nokuhlukaniswa."

Ngemuva kokuthi i-GF ibophene nesamukeli sayo se-GF, ukusayinda okudingekayo ekukhulumeni kwayo kuyaqala.I-GF-GF receptor yenza kusebenze ukuvezwa kwakho kokubili kokusayina kwe-Akt ne-ERK.Ukusebenza kwe-Akt kuzovimbela izindlela ze-2 ngokusebenzisa i-phosphorylation: (1) i-glycogen synthase kinase-3β ekhuthaza ukuwohloka kwe-β-catenin, kanye (2) nomgqugquzeli wokufa ohambisana ne-Bcl-2, onesibopho sokwenza i-apoptosis.Njengoba kushiwo abalobi, i-PRP ingase ikhulise i-vascularization,vimbela i-apoptosis, futhi andise ubude besigaba se-anagen.

igazi lokuqoqwa kwe-prp tube


Isikhathi sokuthumela: Aug-24-2022